# Cabaletta Bio, Inc. (CABA) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Cabaletta Bio, Inc. (CABA) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: CABA -85.39%, SPY +88.08%. Regime CABA CRISIS · SPY BULL. As of Oct 12, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/CABA/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=CABA%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| CABA | -85.39% | -95.90% | -19.00% |
| SPY | +88.08% | -24.49% | +14.79% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| CABA | -28.11% | -57.88% | -88.07% | -85.39% |
| SPY | +18.62% | +36.24% | +86.06% | +88.08% |

## Annual

| Year | CABA | SPY |
|---|---:|---:|
| YTD | -19.00% | +14.79% |
| 2025 | -6.01% | +18.01% |
| 2024 | -89.76% | +25.59% |
| 2023 | +141.49% | +26.73% |
| 2022 | +137.18% | -18.64% |
| 2021 | -69.06% | +7.72% |

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Research context only. Not personalized investment advice.