# BlackRock Health Sciences Trust (BME) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

BlackRock Health Sciences Trust (BME) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: BME +30.51%, SPY +90.43%. Regime BME BEAR · SPY BULL. As of Oct 8, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/BME/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=BME%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| BME | +30.51% | -18.24% | +10.49% |
| SPY | +90.43% | -24.49% | +14.17% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| BME | +22.29% | +21.35% | +36.58% | +30.51% |
| SPY | +16.22% | +38.14% | +85.65% | +90.43% |

## Annual

| Year | BME | SPY |
|---|---:|---:|
| YTD | +10.49% | +14.17% |
| 2025 | +19.31% | +18.01% |
| 2024 | -0.36% | +25.59% |
| 2023 | -0.69% | +26.73% |
| 2022 | -3.81% | -18.64% |
| 2021 | +5.99% | +9.65% |

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Research context only. Not personalized investment advice.