# Astria Therapeutics, Inc. (ATXS) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Astria Therapeutics, Inc. (ATXS) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: ATXS +67.07%, SPY +91.36%. Regime ATXS BEAR · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/ATXS/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=ATXS%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| ATXS | +67.07% | -77.53% | -2.40% |
| SPY | +91.36% | -24.49% | +14.86% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| ATXS | +66.62% | +46.28% | -13.89% | — |
| SPY | +17.26% | +38.01% | +86.77% | +91.36% |

## Annual

| Year | ATXS | SPY |
|---|---:|---:|
| YTD | -2.40% | +14.86% |
| 2025 | +45.93% | +18.01% |
| 2024 | +14.76% | +25.59% |
| 2023 | -48.94% | +26.73% |
| 2022 | +148.17% | -18.64% |
| 2021 | -28.42% | +9.53% |

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Research context only. Not personalized investment advice.