# Apellis Pharmaceuticals, Inc. (APLS) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Apellis Pharmaceuticals, Inc. (APLS) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: APLS +15.84%, SPY +88.08%. Regime APLS BULL · SPY BULL. As of Oct 12, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/APLS/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=APLS%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| APLS | +15.84% | -82.47% | +58.66% |
| SPY | +88.08% | -24.49% | +14.79% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| APLS | +150.79% | -2.12% | -53.43% | — |
| SPY | +18.62% | +36.24% | +86.06% | +88.08% |

## Annual

| Year | APLS | SPY |
|---|---:|---:|
| YTD | +58.66% | +14.79% |
| 2025 | -24.25% | +18.01% |
| 2024 | -47.92% | +25.59% |
| 2023 | +19.05% | +26.73% |
| 2022 | +6.03% | -18.64% |
| 2021 | +33.48% | +7.72% |

---

Research context only. Not personalized investment advice.