# AN2 Therapeutics, Inc. (ANTX) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

AN2 Therapeutics, Inc. (ANTX) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: ANTX -76.62%, SPY +86.64%. Regime ANTX CRISIS · SPY BULL. As of Oct 13, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/ANTX/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=ANTX%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| ANTX | -76.62% | -95.60% | +224.32% |
| SPY | +86.64% | -24.49% | +14.78% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| ANTX | +185.71% | +249.51% | -74.14% | — |
| SPY | +18.61% | +36.22% | +86.97% | +86.64% |

## Annual

| Year | ANTX | SPY |
|---|---:|---:|
| YTD | +224.32% | +14.78% |
| 2025 | -17.99% | +18.01% |
| 2024 | -93.05% | +25.59% |
| 2023 | +110.80% | +26.73% |
| 2022 | -38.12% | -18.64% |
| 2021 | — | +6.90% |

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Research context only. Not personalized investment advice.