# Annexon, Inc. (ANNX) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Annexon, Inc. (ANNX) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: ANNX -81.69%, SPY +91.24%. Regime ANNX RECOVERY · SPY BULL. As of Oct 12, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/ANNX/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=ANNX%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| ANNX | -81.69% | -93.73% | -15.57% |
| SPY | +91.24% | -24.49% | +14.79% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| ANNX | +31.78% | -46.56% | +138.55% | -81.69% |
| SPY | +18.62% | +36.24% | +86.06% | +91.24% |

## Annual

| Year | ANNX | SPY |
|---|---:|---:|
| YTD | -15.57% | +14.79% |
| 2025 | -8.73% | +18.01% |
| 2024 | +5.99% | +25.59% |
| 2023 | -5.22% | +26.73% |
| 2022 | -56.70% | -18.64% |
| 2021 | -46.88% | +9.53% |

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Research context only. Not personalized investment advice.