# Aldeyra Therapeutics, Inc. (ALDX) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Aldeyra Therapeutics, Inc. (ALDX) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: ALDX -89.30%, SPY +90.43%. Regime ALDX CRISIS · SPY BULL. As of Oct 9, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/ALDX/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=ALDX%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| ALDX | -89.30% | -92.30% | -80.38% |
| SPY | +90.43% | -24.49% | +14.17% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| ALDX | -83.84% | -82.45% | -84.12% | -89.30% |
| SPY | +16.22% | +38.14% | +85.65% | +90.43% |

## Annual

| Year | ALDX | SPY |
|---|---:|---:|
| YTD | -80.38% | +14.17% |
| 2025 | -0.77% | +18.01% |
| 2024 | +40.96% | +25.59% |
| 2023 | -49.57% | +26.73% |
| 2022 | +63.00% | -18.64% |
| 2021 | -53.27% | +9.65% |

---

Research context only. Not personalized investment advice.