# Acurx Pharmaceuticals, Inc. (ACXP) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Acurx Pharmaceuticals, Inc. (ACXP) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: ACXP -98.71%, SPY +88.08%. Regime ACXP BEAR · SPY BULL. As of Oct 12, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/ACXP/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=ACXP%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| ACXP | -98.71% | -98.91% | -53.62% |
| SPY | +88.08% | -24.49% | +14.79% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| ACXP | -82.12% | -96.88% | -98.43% | -98.71% |
| SPY | +18.62% | +36.24% | +86.06% | +88.08% |

## Annual

| Year | ACXP | SPY |
|---|---:|---:|
| YTD | -53.62% | +14.79% |
| 2025 | -85.18% | +18.01% |
| 2024 | -79.65% | +25.59% |
| 2023 | -9.67% | +26.73% |
| 2022 | -11.95% | -18.64% |
| 2021 | -12.71% | +7.72% |

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Research context only. Not personalized investment advice.