# Acrivon Therapeutics, Inc. Common Stock (ACRV) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Acrivon Therapeutics, Inc. Common Stock (ACRV) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: ACRV -89.66%, SPY +84.07%. Regime ACRV CRISIS · SPY BULL. As of Oct 14, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/ACRV/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=ACRV%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| ACRV | -89.66% | -95.47% | -30.08% |
| SPY | +84.07% | -24.49% | +13.53% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| ACRV | -1.15% | -76.31% | -70.14% | — |
| SPY | +17.47% | +34.75% | +83.03% | +84.07% |

## Annual

| Year | ACRV | SPY |
|---|---:|---:|
| YTD | -30.08% | +13.53% |
| 2025 | -57.64% | +18.01% |
| 2024 | +20.16% | +25.59% |
| 2023 | -57.48% | +26.73% |
| 2022 | -30.77% | -18.64% |
| 2021 | — | +6.59% |

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Research context only. Not personalized investment advice.