# Abeona Therapeutics Inc. (ABEO) vs State Street SPDR S&P 500 ETF Trust (SPY) · total-return overlay

LOPJLB holding-return compare (5Y). Dividends and splits. Each path starts at 0% from the first adjusted close in the window.

Abeona Therapeutics Inc. (ABEO) vs State Street SPDR S&P 500 ETF Trust (SPY) total return over 5Y: ABEO -79.69%, SPY +88.06%. Regime ABEO CRISIS · SPY BULL. As of Oct 13, 2026. Research only.

- Interactive: https://www.lopjlb.com/vs/ABEO/SPY
- API: `GET /bff/api/bigfive/compare-series?symbols=ABEO%2CSPY&range=5y`

## Window

| Symbol | Window % | Worst drawdown | YTD |
|---|---:|---:|---:|
| ABEO | -79.69% | -90.72% | -14.88% |
| SPY | +88.06% | -24.49% | +14.78% |

## Periods (calendar lookback)

| Symbol | 1Y | 2Y | 3Y | 5Y |
|---|---:|---:|---:|---:|
| ABEO | -16.45% | -27.91% | +9.18% | -79.69% |
| SPY | +18.61% | +36.22% | +86.97% | +88.06% |

## Annual

| Year | ABEO | SPY |
|---|---:|---:|
| YTD | -14.88% | +14.78% |
| 2025 | -10.83% | +18.01% |
| 2024 | +0.72% | +25.59% |
| 2023 | +75.17% | +26.73% |
| 2022 | -66.70% | -18.64% |
| 2021 | -61.80% | +7.72% |

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Research context only. Not personalized investment advice.